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KMID : 1134819970260061181
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 6 p.1181 ~ p.1186
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Effect of Codonopsis lanceolata Water Extract on the Activities of Antioxidative Enzymes in Carbon Tetrachloride Treated Rats
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Han Eun-Gyeong
Cho Soo-Yeul
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Abstract
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This study was performed to investigate the effects of Codonopsis lanceolata water extract on the activities of antioxidative enzymes in carbon tetrachloride treated rats. Male Sprague-Dawley rats were fed until they reached about 110±10g body weight. Thereafter they were divided into normal group(N), carbon tetrachloride treated group(T), carbon tetrachloride and Codonopsis lanceolata water extract treated group(TW). Normal group were fed standard diet and carbon tetrachloride treated group were fed carbon tetrachloride once a week at the level of 0.12ml/100g body weight. Carbon tetrachloride and Codonopsis lanceolata water extract treated group were fed carbon tetrachloride once a week at the level of 0.12ml/100g body weight and Codonopsis lanceolata water extract at the level of 0.1ml/100g body weight once a day. The rats were sacrificed after 6weeks of feeding period. Content of hepatic cytochrome P-450 diminished by carbon tetrachloride was significantly increased by Codonopsis lanceolata water extract. Significant decrease in hepatic xanthine oxidase activity was found in rats treated with Codonopsis lanceolata water extract. The activity of superoxide dismutase was decreased by carbon tetrachloride, but it was significantly increased by Codonopsis lanceolata water extract. The activity of glutathione peroxidase increased by carbon tetrachloride was significantly decreased by Codonopsis lanceolata water extract. The activities of catalase and glutathione S-tran-sferase were not significantly influenced by Codonopsis lanceolata water extract. Contents of glutathione and lipid peroxide were increased by carbon tetrachloride, but they were significantly diminished by Codonopsis lanceolata water extract.
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KEYWORD
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Codonopsis lanceolata, carbon tetrachloride, antioxidative enzymes
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